Über mich
Geboren in Ankara. Mittlere Schulbildung am Privatgymnasium Tevfik Fikret in Ankara. Das Medizinstudium an der Medizinischen Fakultät der Universität Hacettepe 2006 abgeschlossen, nachdem im Rahmen des Erasmus-Programms auch in zwei verschiedenen Krankenhäusern in Frankreich gearbeitet worden war. Im selben Jahr Beginn der Facharztausbildung in Neurologie an der Abteilung für Neurologie der Medizinischen Fakultät der Universität Hacettepe. Für die Dissertation mit dem Titel „RAGE- und NF-kappa-B-Aktivierung bei vaskulitischen Neuropathien und nichtentzündlichen axonalen Neuropathien“ Gewinn des „Preises für junge Forschende auf dem Gebiet der Neuropathie“ der Europäischen Neurologischen Gesellschaft. 2011 mit einem Stipendium der Europäischen Neurologischen Gesellschaft an der Universität Würzburg (Deutschland) Fortsetzung der Arbeiten zu Neuropathien unter Leitung von Prof. Dr. Claudia Sommer, ausgewiesen auf dem Gebiet neuropathischer Schmerzen und Neuropathien. 2012 Abschluss der Facharztausbildung in Neurologie, anschließend staatlicher Pflichtdienst am Staatskrankenhaus Anamur. 2014–2016 Masterabschluss in Neuroimmunologie an der Abteilung für Klinische Neurologische Wissenschaften des Instituts für Neurologische Wissenschaften und Psychiatrie der Universität Hacettepe. 2015 Beginn der Tätigkeit als Assistenzprofessur an der Abteilung für Neurologie der Universität Hacettepe. 2017 Titel „Assoz. Prof. für Neurologie“. 2021–2022 Mitwirkung an klinischen und Laborarbeiten zu Gentherapien bei neuromuskulären Erkrankungen mit Prof. Dr. Jerry Mendell (Entwicklung von Gentherapien bei Spinaler Muskelatrophie (SMA) und Duchenne-Muskeldystrophie) am „Nationwide Children’s Hospital“ (Ohio, Vereinigte Staaten von Amerika). 2023 Titel „Prof. für Neurologie“. Fortsetzung der Arbeiten zu genetischen Erkrankungen im Rahmen der laufenden Promotion an der Abteilung für Medizinische Biologie. Vorstandsmitglied der Arbeitsgruppe für Neuromuskuläre Erkrankungen und Neuropathische Schmerzen der Türkischen Neurologischen Gesellschaft. Neben den klinischen Arbeiten im Bereich klinischer neuromuskulärer Erkrankungen an der Abteilung für Neurologie Durchführung und pathologische Auswertung diagnostischer Muskel-, Nerven-, Muskel-Nerven- und Hautbiopsien im Forschungslabor für Neuromuskuläre Erkrankungen der Abteilung. Gute Englisch- und Französischkenntnisse.
Ausbildung
- Devam EdiyorPromotion — Institut für Gesundheitswissenschaften, Abteilung für Medizinische BiologieUniversität Hacettepe
- 2016Master — Institut für Neurologische Wissenschaften und PsychiatrieUniversität Hacettepe
- 2006Medizinische Fakultät, NeurologieUniversität Hacettepe
- 2006Medizinische FakultätUniversität Hacettepe
- 1999Ankara Özel Tevfik Fikret Gymnasium
Fachgebiete
Veröffentlichungen
Quelle: Akademisches Datenmanagementsystem der Universität Hacettepe (AVESİS) · Alle Veröffentlichungen (86) ↗
Articles 54
- Case Report: Steroid Responsive Pompe Like Inflammatory Myositis With Complete Recovery After Allogeneic HSCTInternational Journal of Rheumatic Diseases, cilt.29, sa.4, 2026 (SCI-Expanded, Scopus)
- Increased epidermal growth factor expression in amyotrophic lateral sclerosis patients: A potential protective mechanism against pressure ulcersTurk Noroloji Dergisi, cilt.32, sa.3, ss.230-236, 2026 (ESCI, Scopus)
- Detection of inflammation and glial cell-related biomarkers in adults with spinal muscular atrophy receiving nusinersen therapyNeurological Sciences, cilt.47, sa.1, 2026 (SCI-Expanded, Scopus)
- Random X chromosome inactivation in female Charcot-Marie-Tooth disease type X1: insights from sural nerve biopsy analysisBMC NEUROLOGY, cilt.25, sa.1, 2025 (SCI-Expanded, Scopus)
- Nivolumab- and ipilimumab-induced myositis, myasthenia gravis, and myocarditis in a patient with metastatic melanomaANTI-CANCER DRUGS, cilt.36, sa.7, 2025 (SCI-Expanded, Scopus)
- Transitioning From Nusinersen to Risdiplam for Spinal Muscular Atrophy in Clinical Practice: A Single-Center ExperienceMUSCLE & NERVE, cilt.71, sa.3, ss.414-421, 2025 (SCI-Expanded, Scopus)
- Clinical and laboratory remission with rituximab in anti-MuSK-positive myasthenia gravisIRISH JOURNAL OF MEDICAL SCIENCE, cilt.193, ss.2989-2994, 2024 (SCI-Expanded, Scopus)
- A novel pathogenic PTRH2 variant indicates seizure association with protein-truncating variants in Infantile-Onset Multisystem Neurologic, Endocrine and Pancreatic Disease (IMNEPD)EUROPEAN JOURNAL OF HUMAN GENETICS, ss.1494, 2024 (SCI-Expanded, Scopus)
- Effect of Follicular T Helper and T Helper 17 Cells-Related Molecules on Disease Severity in Patients with Myasthenia GravisEUROPEAN NEUROLOGY, cilt.87, sa.5-6, ss.223-229, 2024 (SCI-Expanded, Scopus)
- A novel pathogenic PTRH2 variant indicates seizure association with protein-truncating variants in Infantile-Onset Multisystem Neurologic, Endocrine and Pancreatic Disease (IMNEPD)EUROPEAN JOURNAL OF HUMAN GENETICS, ss.1494, 2024 (SCI-Expanded, Scopus)
- Differentiating recurrent Guillain-Barre syndrome and acute-onset chronic inflammatory polyneuropathy: literature reviewACTA NEUROLOGICA BELGICA, cilt.124, ss.1467-1475, 2024 (SCI-Expanded, Scopus)
- VARIABLE PHENOTYPE IN FEMALES WITH HETEROZYGOUS GJB1 MUTATIONJOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2024 (SCI-Expanded, Scopus)
- Recurrent simultaneous central nervous system demyelination with possible peripheral demyelination / nodopathy in a seronegative patientIDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, cilt.77, sa.9-10, ss.357-360, 2024 (SCI-Expanded, Scopus)
- Nusinersen for adults with spinal muscular atrophyNeurological Sciences, cilt.44, sa.7, ss.2393-2400, 2023 (SCI-Expanded, Scopus)
- The evaluation of small fibers in multiple sclerosisMultiple Sclerosis and Related Disorders, cilt.72, 2023 (SCI-Expanded, Scopus)
- Two distinct skeletal muscle microRNA signatures revealing the complex mechanism of sporadic ALSACTA NEUROLOGICA BELGICA, cilt.122, sa.6, ss.1499-1509, 2022 (SCI-Expanded, Scopus)
- Comprehensive evaluation of velopharyngeal function in myasthenia gravis patientsACTA NEUROLOGICA BELGICA, cilt.122, sa.5, ss.1229-1236, 2022 (SCI-Expanded, Scopus)
- Identifying a Cut-off Point for Timed Up and Go Test in Neuromuscular DiseasesTURKISH JOURNAL OF NEUROLOGY, cilt.28, sa.1, ss.6-9, 2022 (ESCI, Scopus, TRDizin)
- The functional and structural evaluation of small fibers in asymptomatic carriers of TTR p.Val50Met (Val30Met) mutationNEUROMUSCULAR DISORDERS, cilt.32, sa.1, ss.50-56, 2022 (SCI-Expanded, Scopus)
- Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension studyMuscle and Nerve, cilt.64, sa.6, ss.662-669, 2021 (SCI-Expanded, Scopus)
- One Disease with two Faces: Semidominant Inheritance of a Novel HTRA1 Mutation in a Consanguineous FamilyJOURNAL OF STROKE & CEREBROVASCULAR DISEASES, cilt.30, sa.9, 2021 (SCI-Expanded, Scopus)
- The evaluation of small fibers in asymptomatic carriers of Val30Met mutation: Results of three years follow-upJOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, cilt.26, sa.3, ss.379, 2021 (SCI-Expanded, Scopus)
- Biologia Futura: the importance of 3D organoids-a new approach for research on neurological and rare diseasesBIOLOGIA FUTURA, cilt.72, sa.3, ss.281-290, 2021 (SCI-Expanded, Scopus)
- A Rare Cause of Dystonia: Spinal MeningiomaTURKISH JOURNAL OF NEUROLOGY, cilt.27, sa.2, ss.215-216, 2021 (ESCI, Scopus, TRDizin)
- Reliability and Validity of Turkish Myasthenia Gravis-Activities of Daily Living ScaleOTJR-OCCUPATION PARTICIPATION AND HEALTH, cilt.41, sa.2, ss.101-107, 2021 (SSCI, Scopus)
- Psychosocial Adjustment and Adherence to Medication in Patients with Myasthenia GravisGAZI MEDICAL JOURNAL, cilt.32, sa.3, ss.371-376, 2021 (ESCI, Scopus)
- Organelle Positioning in Neurons and Skeletal Muscle CellsGAZI MEDICAL JOURNAL, cilt.32, ss.341-347, 2021 (ESCI, Scopus)
- Consistent improvement with eculizumab across muscle groups in myasthenia gravisAnnals of Clinical and Translational Neurology, cilt.7, sa.8, ss.1327-1339, 2020 (SCI-Expanded, Scopus)
- Trigeminal sensory-motor neuropathy in a patient with mixed connective tissue disease and review of the literatureNEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, cilt.37, sa.3, ss.148-151, 2020 (SCI-Expanded, Scopus, TRDizin)
- A Novel Amplification-Refractory Mutation System-PCR Strategy to Screen MT-TL1 Pathogenic Variants in Patient RepositoriesGENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.24, sa.3, ss.165-170, 2020 (SCI-Expanded, Scopus)
- Giant cell myositis associated with myasthenia gravis and thymomaNEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, cilt.36, sa.4, ss.236-237, 2019 (SCI-Expanded, Scopus, TRDizin)
- Long-term safety and efficacy of eculizumab in generalized myasthenia gravisMuscle and Nerve, cilt.60, sa.1, ss.14-24, 2019 (SCI-Expanded, Scopus)
- Laboratory diagnosis of metachromatic leukodystrophy requires more than arylsulfatase A assayFEBS OPEN BIO, cilt.9, ss.199, 2019 (SCI-Expanded, Scopus)
- Two sisters with anti-MuSK-positive myasthenia gravisCLINICAL NEUROLOGY AND NEUROSURGERY, cilt.182, ss.17-18, 2019 (SCI-Expanded, Scopus)
- Establishment of primary myoblast cell cultures from cryopreserved skeletal muscle biopsies to serve as a tool in related research & development studiesJOURNAL OF THE NEUROLOGICAL SCIENCES, cilt.393, ss.100-104, 2018 (SCI-Expanded, Scopus)
- Ocular surface alterations and in vivo confocal microscopic characteristics of corneas in patients with myasthenia gravisEUROPEAN JOURNAL OF OPHTHALMOLOGY, cilt.28, sa.5, ss.541-546, 2018 (SCI-Expanded, Scopus)
- The histopathological evaluation of small fiber neuropathy in patients with vitamin B12 deficiencyACTA NEUROLOGICA BELGICA, cilt.118, sa.3, ss.405-410, 2018 (SCI-Expanded, Scopus)
- ERLIN1 mutations cause teenage-onset slowly progressive ALS in a large Turkish pedigreeEUROPEAN JOURNAL OF HUMAN GENETICS, cilt.26, sa.5, ss.745-748, 2018 (SCI-Expanded, Scopus)
- Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre studyThe Lancet Neurology, cilt.16, sa.12, ss.976-986, 2017 (SCI-Expanded, Scopus)
- Myophosphorylase (PYGM) mutations determined by next generation sequencing in a cohort from Turkey with McArdle diseaseNEUROMUSCULAR DISORDERS, cilt.27, sa.11, ss.997-1008, 2017 (SCI-Expanded, Scopus)
- CELLULAR INFILTRATES IN SKIN AND SURAL NERVE OF PATIENTS WITH POLYNEUROPATHIESMUSCLE & NERVE, cilt.55, sa.6, ss.884-893, 2017 (SCI-Expanded, Scopus)
- New mutations and genotype-phenotype correlation in late-onset Pompe patientsACTA NEUROLOGICA BELGICA, cilt.117, sa.1, ss.269-275, 2017 (SCI-Expanded, Scopus)
- Single-pulse Transcranial Magnetic Stimulation in Amyotrophic Lateral Sclerosis: Experience of a single institutionJOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.34, sa.1, ss.70-75, 2017 (SCI-Expanded, Scopus, TRDizin)
- Dysferlinopathy: A Case Report and Literature UpdateISTANBUL MEDICAL JOURNAL, cilt.17, sa.4, ss.136-140, 2016 (ESCI, TRDizin)
- Autoimmune stormEUROPEAN JOURNAL OF NEUROLOGY, cilt.23, ss.437, 2016 (SCI-Expanded, Scopus)
- The evaluation of small fibres in asymptomatic patients with Val30Met mutationEUROPEAN JOURNAL OF NEUROLOGY, cilt.23, ss.231, 2016 (SCI-Expanded, Scopus)
- Spinal muscular atrophy type III: Molecular genetic characterization of Turkish patientsEUROPEAN JOURNAL OF MEDICAL GENETICS, cilt.58, sa.12, ss.654-658, 2015 (SCI-Expanded, Scopus)
- The Activation of RAGE and NF-KB in Nerve Biopsies of Patients with Axonal and Vasculitic NeuropathyNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.52, sa.3, ss.279-282, 2015 (SCI-Expanded, Scopus, TRDizin)
- Three Turkish families with different transthyretin mutationsNEUROMUSCULAR DISORDERS, cilt.25, sa.9, ss.686-692, 2015 (SCI-Expanded, Scopus)
- Voltage gated calcium channel antibody-related neurological diseases.World journal of clinical cases, cilt.3, ss.293-300, 2015 (SCI-Expanded, Scopus)
- CUTANEOUS ACTIVATION OF RAGE IN NONSYSTEMIC VASCULITIC AND DIABETIC NEUROPATHYMUSCLE & NERVE, cilt.50, sa.3, ss.377-383, 2014 (SCI-Expanded, Scopus)
- The Course of Myasthenia Gravis with Systemic Lupus ErythematosusEUROPEAN NEUROLOGY, cilt.72, ss.326-329, 2014 (SCI-Expanded, Scopus)
- Myasthenia Gravis; Single Entity, Variable Clinical Features: Ten Years of Clinical Experience in a Tertiary Care Center Ten Years Clinical Experience of a Tertiary Care CenterJOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.30, sa.1, ss.135-143, 2013 (SCI-Expanded, Scopus, TRDizin)
- 'Jaw clenching' in anti-Ri - Antibody-associated paraneoplastic syndromePARKINSONISM & RELATED DISORDERS, cilt.19, sa.1, ss.132-133, 2013 (SCI-Expanded, Scopus)
Conference papers 32
- The effect and challenges of nusinersen treatment in adult spinal muscular atrophy patients - preliminary results6th Congress of the European-Academy-of-Neurology (EAN), ELECTR NETWORK, 23 - 26 Mayıs 2020, cilt.27, ss.625, (Özet Bildiri)
- Multimodal Assessment Of Intensive Care Unit-Acquired Weakness (ICU-AW) In Severe Acute Stroke Patients2019 PNS Meeting, 22 - 26 Haziran 2019, (Özet Bildiri)
- Erişkin Kas Hastalarında Fiziksel Aktiviteyi Objektif ve Subjektif Olarak Değerlendiren Yöntemlerin KarşılaştırılmasıTND II. Nöromusküler Hastalıklar Kongresi, İzmir, Türkiye, 19 - 21 Nisan 2019, (Özet Bildiri)
- Nusinersen İlacı İçin Başvuruda Bulunan Spinal Musküler Atrofi Tip 2 ve Tip 3 Tanılı Hastaların ProfiliTND II. Nöromusküler Hastalıklar Kongresi, İzmir, Türkiye, 19 - 21 Nisan 2019, (Özet Bildiri)
- Erişkin Nöromusküler Hastalarda Düşme Öyküsünün AktiviteLimitasyonu ve Gövde Bozukluk Düzeyi ile İlişkisinin İncelenmesiTND II. Nöromusküler Hastalıklar Kongresi, İzmir, Türkiye, 19 - 21 Nisan 2019, (Özet Bildiri)
- Erişkin Kas Hastalarında Fiziksel Aktivite ile İlişkili Faktörlerin BelirlenmesiTND II. Nöromusküler Hastalıklar Kongresi, İzmir, Türkiye, 19 - 21 Nisan 2019, (Özet Bildiri)
- Kas Hastalarında Farklı Yüksekliklerden Oturmadan Ayağa Kalkma Sırasında Uyluk Kaslarının Aktivasyon Seviyelerinin İncelenmesiTND II. Nöromusküler Hastalıklar Kongresi, İzmir, Türkiye, 19 - 21 Nisan 2019, (Özet Bildiri)
- Nöroloji Yoğun Bakım Ünitesi'ndeki İnme Hastalarında Yoğun Bakım Ünitesinde Edinilmiş Güçsüzlüğün (YBÜ-EG) Multimodal İncelemesi35. ULUSAL KLİNİK NÖROFİZYOLOJİ EEG-EMG KONGRESİ, Muğla, Türkiye, 3 - 07 Nisan 2019, (Özet Bildiri)
- Differentially Expressed microRNA Profile in Skeletal Muscle Tissue of Sporadic ALS Patients71st Annual Meeting of the American-Academy-of-Neurology (AAN), Pennsylvania, Amerika Birleşik Devletleri, 4 - 10 Mayıs 2019, cilt.92, (Özet Bildiri)
- The expression of epidermal growth factor (EGF) and keratinocyte growth factor (KGF) in skin biopsy of amyotrophic lateral sclerosis patients70th Annual Meeting of the American-Academy-of-Neurology (AAN), Los-Angeles, Şili, 21 - 27 Nisan 2018, cilt.90, (Özet Bildiri)
- Myastenia gravis hastalarında altı dakika yürüyüş testinin kullanımı1. Kardiyopulmoner Rehabilitasyon Kongresi, Türkiye, 22 - 25 Kasım 2017, cilt.29, (Özet Bildiri)
- Myastenia gravisli bireylerde fizisel kapasitenin solunum fonksiyonları, yaşam kalitesi ve özür seviyesi ile ilişkisi53. Ulusal Nöroloji Kongresi, Türkiye, 24 - 30 Kasım 2017, (Özet Bildiri)
- Myastenia gravis hastalarının hastalığa psikososyal uyumu ve ilaç uyumlarının belirlenmesi.. 5. Uluslararası, 16. Ulusal Hemşirelik Kongresi, Ankara, Türkiye, 5 - 08 Kasım 2017, (Özet Bildiri)
- VECTOR-BORNE VIRAL INFECTIONS IN GUILLAIN BARRE SYNDROME PATIENTSPeripheral-Nerve-Society Meeting, Sitges, İspanya, 8 - 12 Temmuz 2017, cilt.22, ss.349-350, (Özet Bildiri)
- Acute myopathy in patients who are using short-term and low-dose systemic glucucorticoids: Preliminary findings16th European Congress of Internal Medicine, 31 Ağustos - 02 Eylül 2017, (Özet Bildiri)
- Recurrent peripheral and central demyelination in a seronegative patientperipheral Nerve Society Meeting, 8 Temmuz - 13 Eylül 2017, (Özet Bildiri)
- Low levels of SMN cause alterations in microtubule associated protein 1b21th Annual Spinal Muscular Atrophy Researcher Meeting, Orlando, Amerika Birleşik Devletleri, 29 Haziran - 02 Temmuz 2017, (Özet Bildiri)
- The Histopathological Evaluation of Small Fiber Neuropathy in Patients with Vitamin B12 Deficiency68th Annual Meeting of the American-Academy-of-Neurology (AAN), Vancouver, Kanada, 15 - 21 Nisan 2016, cilt.86, (Özet Bildiri)
- Myastenia Gravis de Velofaringeal Fonksiyonun Araştırılması4. YUTMA BOZUKLUKLARI KONGRESİ, Türkiye, 19 - 21 Kasım 2015, (Özet Bildiri)
- A RARE CAUSE OF LUMBOSACRAL PLEXOPATHY: BLADDER DIVERTICULUMBiennial Meeting of the Peripheral-Nerve-Society, Quebec, Kanada, 27 Haziran - 02 Temmuz 2015, cilt.20, ss.166-167, (Özet Bildiri)
- A HEREDITARY AMYLOID POLYNEUROPATHY FAMILY DUE TO VAL30MET MUTATION WITH AN INDEX CASE PRESENTED LIKE CIDPBiennial Meeting of the Peripheral-Nerve-Society, Quebec, Kanada, 27 Haziran - 02 Temmuz 2015, cilt.20, ss.103, (Özet Bildiri)
- A novel mutation in the HTRA1 gene in a Turkish family with CARASIL1st Congress of the European-Academy-of-Neurology, Berlin, Almanya, 20 - 23 Haziran 2015, cilt.22, ss.258, (Özet Bildiri)
- The incidence of Pompe disease in patients with vacuolar myopathy: a pilot study of a tertiary care center1st Congress of the European-Academy-of-Neurology, Berlin, Almanya, 20 - 23 Haziran 2015, cilt.22, ss.623, (Özet Bildiri)
- The time course of pseudo-conduction blocks in a patient with vasculitic neuropathyJoint Congress of European Neurology, İstanbul, Türkiye, 31 Mayıs - 03 Haziran 2014, cilt.261, (Özet Bildiri)
- Three families with hereditary amyloid polyneuropathy with three different mutationsJoint Congress of European Neurology, İstanbul, Türkiye, 31 Mayıs - 03 Haziran 2014, cilt.261, (Özet Bildiri)
- NUSİNERSEN TEDAVİSİ ALAN ERİŞKİN SPİNAL MUSKÜLER ATROFİ HASTALARINDA İNFLAMASYON VE GLİAL HÜCRE İLİŞKİLİ BİYOBELİRTEÇLERİN TESPİTİ
- MİYASTENİK KRİZ İLE BAŞVURAN HASTALARDA YARDIMCI FOLİKÜLER T HÜCRE (TFH) VE YARDIMCI T HÜCRE 17 (TH17) İLİŞKİLİ SİTOKİNLERİN TEDAVİ ÖNCESİ VE SONRASI DEĞİŞKENLİĞİ
- Evaluation of the Role of Glial Factors in the Pathogenesis of Spinal Muscular Atrophy
- Serum Cytokines Levels in Patients with Myasthenia Gravis and Their Changes After Treatment
- MME MUTASYONUNA BAĞLI DEMİYELİNİZAN NÖROPATİ
- The evaluation of small fibers in asymptomatic carriers of Val30Met mutation: Results of three years follow-up
- Multimodal Assessment of Intensive Care Unit- Acquired Weakness in Severe Stroke Patients
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